Poxet 60 medicine is taken once as needed. It is advised to take this pill 1-3 hours before sexual problems. You should not take more than one pill in 24 hours. Unless you are dealing with sexual problems every 24 hours, you may not want to take this medicine every day. If the reuptake of 5-hydroxytryptamine by the primary plant cell (pre-synaptic) is blocked, this means that too much 5-hydroxytryptamine is left for the receiving plant cell (post-synaptic).